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Active ingredient for Alzheimer’s Disease - Secondary indication of an approved NSAID
- New therapeutic approach for Alzheimer treatment
- NSAIDs influence the APP (amyloid precursor protein) expression and processing by reduction of the Prostaglandin E2 induced APP expression
- Current stage of development: Phase II
- Keywords: NSAID, neurodegenerative disease, dementia, beta-Amyloid
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Artificial sphincter - Prevention of incontinence
- Artificial sphincter for the prevention of urinary and fecal incontinence, erectile dysfunction, reflux and obesity
- Permanent process control
- Considerably improved quality of life
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Artificial urinary bladder - Total substitution of the bladder function
- Artificial urinary bladder for the total substitution of the bladder function
- Permanent process control
- Reduction of the risk of additional operations
- Considerably improved quality of life
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Beta-lactam antibiotics - Control of multiresistant pathogens
- Innovative beta-lactam antibiotics for the treatment of bacterial (Gram-positive and Gram-negative) infectious diseases
- Broad spectrum of efficacy also against multiresistant pathogens (MRSA, VRE, among others)
- Accessibility of proprietary beta-lactam antibiotics via biotransformation
- Current stage of development: active ingredient optimization and determination of the antimicrobial efficacy spectrum
- Keywords: beta-lactam antibiotics, cephalosporin, antibiotics, MRSA, VRSA
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Bioavailability - Highly efficient, orally available prodrug derivatives
- Platform technology for the synthesis of highly efficient prodrug derivatives of guanidine- and amidine-based active ingredients
- Improvement of bioavailability of active pharmaceutical ingredients in the body, allowing the oral administration of drugs that are currently only available as injectable or inhalable formulations
- Applicable for several antiviral and anti-infectious active ingredients, as well as blood coagulation inhibitors
- Current stage of development: preclinical evaluation of a blood coagulation inhibitor and an antiviral active ingredient
- Keywords: prodrugs, anticoagulant, factor Xa inhibitor, antiinfective
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Biopolymers - High-yield and environmentally friendly production
- Optimized, metabolic modified microorganisms for the cost-effective production of biopolymers
- Production of biodegradable biopolymers with improved mechanical properties for various industrial applications
- Environmentally friendly and simple production due to extracellular product release
- Current stage of development: optimization of various over-producer strains and upscaling
- Keywords: polyhydroxyalkanoates (PHA,) polyhydroxybutyrates (PHB), biodegradable genetic, metabolic engineering, Pseudomonas, Alcanivorax
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Cleaning machine with new steering concept for riding scrubber driers
- The new wheel/brush positioning and steering conecpt enables improved cleaning and a noticeable saving in time and costs
- The innovative wheel and steering concept for scrubbersweepers optimizes existing systems of renowned manufacturers by the improved manoeuvrability and steerability
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Cyclic peptides - Optimization of natural peptide active ingredients
- Platform technology for chemo-enzymatic synthesis of complex, cyclic peptides
- Almost unlimited possibilities for the manufacturing of proprietary natural substance derivatives
- Easy manufacturing of combinatorial active ingredient libraries and the high hit-rate for the optimization of natural lead compounds
- Current stage of development: successful implementation for several natural cyclic peptides (antibiotics, antimycotics, oncological preparations)
- Keywords: antibiotics, antimycotics, oncologics, drug development, chemo-enzymatic synthesis, Tyrocidine A
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Diazonium salts as coupling reagents for active-substance synthesis
- Cost-effective one-pot reactions with diazonium salts in metal-catalyzed cross-coupling reactions
- The use of diazonium salts can both reduce the number of synthetic steps and considerably increase reaction yields
- Increased efficiency by avoiding protecting groups
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Diazonium salts as coupling reagents for active-substance synthesis
- Cost-effective one-pot reactions with diazonium salts in metal-catalyzed cross-coupling reactions
- The use of diazonium salts can both reduce the number of synthetic steps and considerably increase reaction yields
- Increased efficiency by avoiding protecting groups
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DNA-detector - Terahertz detection for gene analysis
- Label free detection
- Reduction of process steps and cost
- Development of a microarray chip and detector for gene analysis using terahertz radiation
- Fast and simple reading of microarrays
- Suitable for archiving and quality control in diagnostics
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Electrochromic laminated glass
- The light transmittance of the laminate panes can be set to any value between 8% and 75%.
- High transmission in a decolorized condition, due to lower amounts of tungsten oxide
- Switching behavior also in the near infrared range – the total energy transfer ratio (amount of heat in incident light) can be changed
- Layer production through electrochemical deposition from aqueous solutions
- Extremely low manufacturing costs
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ExMeTrA - Miniaturised extracorporeal circulatory support system
- Miniaturized oxygenator for the cardiopulmonary bypass with integrated pump and efficient gas exchange
- Very low priming volume (significantly below 80 ml)
- Pulsatile
- Also suitable for pediatric applications
- Transportable
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Flame retardants - New class of halogen-free compounds
- New halogen-free flame retardants with broad applicability
- Replacement of toxic bromine compounds possible
- Good solubility and high stability
- Cost-effective production through short synthetic routes
- Low rates of migration in polymers
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Flexible thin-film solar cell
- The patented thin film solar cell is comprised of semiconducting layers, which are applied to both sides of glass/carbon fibre fabrics by means of spraying.
- Application of the semiconducting layers by means of spraying cyclopentasilane under noble gas atmosphere
- Double-sided coating corresponds to the parallel switching of two cells
- Use of carbon fibres as contact
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High resolution sensor system for flow measuring
- Result of this innovative concept is an energy self-sufficient sensor system with high resolution and dynamic range
- The patented flow meter is characterized by using a permanent magnet and special low-noise contact elements
- An additional advantage in comparison to conventional MID is a more precise measurement even at low flow rates and for minimally-conductive fluids
- Possible application areas are for example food-technology, medical, pharmacy, chemistry and water supply industry
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Hydrogel scaffolding matrix - Production of cartilage replacement material
- The procedure permits the production of cartilage replacement material (knee) with flexible, directed pore structures
- Biodegradable material
- Elastic material showing high stress resiliency
- Low manufacturing cost
- Integration of cells and / or active ingredients
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Impact Modifier - Polymer additive on basis of nano technology
- Nano structure from polyurethan
- Cost-effective production due to polymerisation in reactive diluents
- Increased transparency of the polymers
- Improved impact strength, scratch resistance as well as pull-out and shear strength
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Innovation in volumetric nano/picoliter microdispensing
- Contact free high speed dispenser providing highly accurate single drop
- Suitable for a wide range of media and highly viscose solutions
- Low cost disposable cartridges
- Heatable cartridges separate from piezo actuator
- Low manufacturing costs
- Independent of particle tension and particle contamination over a wide range
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Innovative preservative / disinfection agents
- Consists out of cost-effective compounds (benzoic acid, sorbic acid) with food grades
- Mode of action is based on compound activation of long-term stable micelles
- Areas of application are the disinfection of food packages, in the industrial cleaning sector and in hospitals
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Intelligent (manual) welding torch (MIG/MAG – WIG)
- New type of welding torch enables automatic detection of welding positions by integrated sensor technology
- Welding defects can be greatly reduced
- Guaranteed quality combined with time saving of unnecessary parameter adjustment relieves the welder and ensures an optimal process control
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Metal catalysed recrystallisation of amorphous thin films
- The production of crystalline silicon thin films on inexpensive substrates, such as glass, is of fundamental importance for large size thin film solar cells. The patented titanium-supported metal-induced layer exchange process is a solution for the quick transformation of amorphous into polycrystalline silicon layers.
- Layer system: Glass/metal/metal oxide/a-Si
- Process: Anneal below the eutectic temperature | Duration: several seconds up to hours
- Result: Glass/poly-Si/metal/metal oxide
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Miniature channel heat exchanger
- Enables very efficient heat transfer for the specific cooling or heating of fluids
- The patented design generates mini-turbulences, which optimize temperature distribution within the fluids
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New gypsum mixture - Improvement of the physical properties of gypsum
- The use of this new gypsum mixture considerably improves the bending tensile strengths of current gypsum
- Water absorption of plasterboard is reduced
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Organic semi-conductors - Efficient production of high-stability substances
- Cost-effective production of tetracene compounds for organic light-emitting diodes
- Soluble in organic solvents
- Ideal properties such as durability and conductivity since not prone to oxidation
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Oxidation of olefines - New procedure for higher valuable plastic precursors
- For the first time, butylene oxide and other longer-chain epoxides can also be produced on an industrial scale using this procedure in addition to ethylene oxide and propylene oxide
- The procedure is based on a highly efficient direct oxidation process using ozone
- Very high yields and selectivities have been achieved
- The procedure can be scaled up to large-scale industrial production
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Phosphanes - Efficient chiral catalysts
- Highly effective catalysis of chiral hydrogenations and C-C coupling reactions
- The new catalyst system enables very high enatiomeric excesses
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Phosphanes - Efficient procedure for coupling heterocycles
- The procedure enables economizing to be done in the production of numerous pharmaceuticals, since the number of synthetic steps can be reduced and higher yields are achieved
- Easy access and simple separation with high purity during the procedure
- Use of trialkylsilyl-substituted heterocycles with halogen-substituted aromatic compounds possible without catalyst system
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Pulp production from one-year biomass such as wheat straw, bagasse, etc.
- New and highly efficient chemical procedure for paper pulp manufacturing
- The procedure is a closed-cycle process, thus setting new standards in terms of efficiency and environmental compatibility
- The procedure can be used with straw, bagasse and other kinds of biomass
- By-products such as lignin can be cleanly separated and additionally marketed as high-quality products
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Pyrimidine derivatives - Effective broad-band antiviral active ingredients
- Innovative pyrimidine derivatives for the treatment of entero- and rhinoviral infections (e.g. the common cold, myocarditis, meningitis)
- Broad efficacy spectrum also against currently resistant viruses
- Extensive in vivo studies confirm the good tolerance, high metabolic stability and efficacy
- Current stage of development: active ingredient development phase completed; start of the preclinical development phase
- Keywords: antiviral drugs, anti-infectives, Rhinovirus, Enterovirus
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Raw sausage - Improvement of the ripening process and of cut resistance through folic acid
- By adding folic acid during the ripening process, the use of starter cultures is no longer necessary
- The ripening process is made considerably more efficient, since aroma and cut resistance are attained more quickly and mold formation is improved
- In addition to the financial advantages of the production process, folic acid also has health-promoting effects
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Rotary screen printing machine – Screen printing using a rotary method with up to 8,800 prints per h
- Can be used as a simple screen printing machine or may be integrated into existing machines in the 2-1 system
- Full-coverage or partial, time, and quantity controlled ink release due to a fixed screen printing plate expands usage in the industrial sector
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Solar panel in insulating glass technology
- Patented construction of solar thermal modules consists of an insulating glass compound in which an absorber sheet is integrated
- High thermal insulation through insulating glass construction
- Low heat transfer coefficient (k value) through special coatings
- Integration on roofs and facades
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Solar-active coated thin films based on metal semi-conductor contact
- The novel production method (patent pending) exhibits low process complexity and enables inexpensive production of thin-film solar cells with a variable form factor.
- The wide band gap, UV-sensitive absorber is based on TiO2, and may be deposited onto commercially available glass substrates without vacuum or high temperature process steps.
- The technology enables production of PV modules with high optical transmission, which may be used e.g. as facade elements to address the emerging market of Building Integrated Photovoltaics (BIPV).
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Sugar melting - New continuous process
- New process derived from fluid dynamics, which enables sugar melting at a very high qualitative level in a continuous process
- In the process, both carbonization and time-consuming cleaning can be avoided, thus contributing to cost-effective production
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Tool bag with integrated recovery device for falling tools
- The presented invention prevents such accidents due to the fact that the tool belt is able to keep falling tools close to the body - thanks to a retrieving facility
- Due to a retrieving facility, the presented invention prevents accidents due to the fact that the tool belt is able to keep falling tools close to the body.
- The coupling device between the tool and the tool bag consists of a safety cord which is automatically winded up into a coil
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Variodynamic compressed air diaphragm pump
- Compact, one or multi-channel peristaltic metering unit which uses a pneumatic diaphragm drive
- Self-priming microprecision removal, discharge and metering of one or more substances at a programmable clock speed
- No moving mechanics, very long service life, lowest operating and maintenance costs
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Whole-cell catalyst - Surface-presented enzymes for biocatalysis etc.
- Platform technology for highly efficient surface display of biocatalysts and proteins
- High enzyme stability as well as implementation of non-membrane-standard substrates, simple separation and reusability
- Possible applications in biocatalysis, active ingredient production, bio-analytics, and screening
- Current stage of development: several prototypes for industrial applications and up-scaling available
- Keywords: biocatalysis, surface display, whole-cell biotransformation, nitrilase
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The technologies presented here are part of a patent value fund that was created by a major German bank and an independent initiator. The patents are not the property of IPB AG. IPB AG advises the patent investment fund with regard to the selection of sustainable patents and provides support for further development and licensing.
