New Technologies from the Biotechnology / Pharmaceutical Sector
The patent portfolio currently focuses on drug development and platform technology projects. Each project is carefully assessed in a comprehensive technical, patent, and economical evaluation process. After an R&D phase lasting from one to three years, licensees get access to economically attractive projects and/or candidates for drug development. Depending on the development stage of a drug development candidate, preclinical and/or phase I/II studies are conducted. The proof of concept is, at the very minimum, provided for platform technologies.
The option of customizing development for the industry partners exists for a limited number of potential licensees in some projects. Please contact us if you are interested in a development cooperation.
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Active ingredient for Alzheimer’s Disease - Secondary indication of an approved NSAID
- New therapeutic approach for Alzheimer treatment
- NSAIDs influence the APP (amyloid precursor protein) expression and processing by reduction of the Prostaglandin E2 induced APP expression
- Current stage of development: Phase II
- Keywords: NSAID, neurodegenerative disease, dementia, beta-Amyloid
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Beta-lactam antibiotics - Control of multiresistant pathogens
- Innovative beta-lactam antibiotics for the treatment of bacterial (Gram-positive and Gram-negative) infectious diseases
- Broad spectrum of efficacy also against multiresistant pathogens (MRSA, VRE, among others)
- Accessibility of proprietary beta-lactam antibiotics via biotransformation
- Current stage of development: active ingredient optimization and determination of the antimicrobial efficacy spectrum
- Keywords: beta-lactam antibiotics, cephalosporin, antibiotics, MRSA, VRSA
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Pyrimidine derivatives - Effective broad-band antiviral active ingredients
- Innovative pyrimidine derivatives for the treatment of entero- and rhinoviral infections (e.g. the common cold, myocarditis, meningitis)
- Broad efficacy spectrum also against currently resistant viruses
- Extensive in vivo studies confirm the good tolerance, high metabolic stability and efficacy
- Current stage of development: active ingredient development phase completed; start of the preclinical development phase
- Keywords: antiviral drugs, anti-infectives, Rhinovirus, Enterovirus
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Bioavailability - Highly efficient, orally available prodrug derivatives
- Platform technology for the synthesis of highly efficient prodrug derivatives of guanidine- and amidine-based active ingredients
- Improvement of bioavailability of active pharmaceutical ingredients in the body, allowing the oral administration of drugs that are currently only available as injectable or inhalable formulations
- Applicable for several antiviral and anti-infectious active ingredients, as well as blood coagulation inhibitors
- Current stage of development: preclinical evaluation of a blood coagulation inhibitor and an antiviral active ingredient
- Keywords: prodrugs, anticoagulant, factor Xa inhibitor, antiinfective
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Biopolymers - High-yield and environmentally friendly production
- Optimized, metabolic modified microorganisms for the cost-effective production of biopolymers
- Production of biodegradable biopolymers with improved mechanical properties for various industrial applications
- Environmentally friendly and simple production due to extracellular product release
- Current stage of development: optimization of various over-producer strains and upscaling
- Keywords: polyhydroxyalkanoates (PHA,) polyhydroxybutyrates (PHB), biodegradable genetic, metabolic engineering, Pseudomonas, Alcanivorax
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Cyclic peptides - Optimization of natural peptide active ingredients
- Platform technology for chemo-enzymatic synthesis of complex, cyclic peptides
- Almost unlimited possibilities for the manufacturing of proprietary natural substance derivatives
- Easy manufacturing of combinatorial active ingredient libraries and the high hit-rate for the optimization of natural lead compounds
- Current stage of development: successful implementation for several natural cyclic peptides (antibiotics, antimycotics, oncological preparations)
- Keywords: antibiotics, antimycotics, oncologics, drug development, chemo-enzymatic synthesis, Tyrocidine A
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Diazonium salts as coupling reagents for active-substance synthesis
- Cost-effective one-pot reactions with diazonium salts in metal-catalyzed cross-coupling reactions
- The use of diazonium salts can both reduce the number of synthetic steps and considerably increase reaction yields
- Increased efficiency by avoiding protecting groups
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Whole-cell catalyst - Surface-presented enzymes for biocatalysis etc.
- Platform technology for highly efficient surface display of biocatalysts and proteins
- High enzyme stability as well as implementation of non-membrane-standard substrates, simple separation and reusability
- Possible applications in biocatalysis, active ingredient production, bio-analytics, and screening
- Current stage of development: several prototypes for industrial applications and up-scaling available
- Keywords: biocatalysis, surface display, whole-cell biotransformation, nitrilase
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The technologies presented here are part of a patent value fund that was created by a major German bank and an independent initiator. The patents are the property of the initiators. IPB AG advises the patent investment fund with regard to the selection of sustainable patents and provides support for further development and licensing.
